The practice of using saliva as a means of treating wounds in Gorontalo culture has been going on from generation to generation. People believe that there are many more benefits and uses of saliva. This study describes analytic observations of BPJS patients in choosing traditional and modern treatments, especially Wadengo treatment. Another goal is to conduct experiments on Wadengo's saliva by looking at the content, viscosity, clarity, and levels of acids and bases. This research employs a Mixed-Methods research design. This study also uses analytic observational with a cross-sectional study design, and a research library to obtain data to compare research results in the field and existing information. The results showed that dhikr can affect the content of saliva in treatment. The mysticism of saliva resides in the content of the saliva itself, which contains a protein called histatin. This histatin is an antimicrobial and antifungal protein and has been shown to play a role in closing wounds, this histatin also has antifungal properties and can prevent its absorption in the digestive tract. This is proven by the lab results about saliva on healers who use the dhikr method and do not use dhikr. In the medicine dhikr, the examination results found that the saliva was not cloudy and the pH was normal. Meanwhile, the medicine that does not dhikr results in the condition of the saliva being cloudy and the pH contained in the saliva being less than normal.