Jobs that force workers to be in work postures that are not ergonomic cause workers to experience fatigue more quickly and cause musculoskeletal complaints (MSDs). The purpose of this research is to find out the body parts of seaweed farmers who experience MSD complaints and examine the handling of MSDs using local wisdom in Sanrobone District, Takalar Regency. This study employs mixed methods research which combines both quantitative and qualitative methods. Quantitative data was collected by giving questionnaires to 706 respondents using the Nordic body map method to describe MSDs complaints felt by seaweed farmers.  Qualitative data was obtained through in-depth interview, using an ethnographic approach to examine the handling of complaints of musculoskeletal disorders (MSDs) based on local wisdom. The results of data analysis showed that 328 seaweed farmers experienced complaints of MSDs (46.5%), with a working period of > 1 year. The most common MSDs complaints were back pain (33.1%), low back pain (36%), and pain in the lower body (thighs to feet) as much as 19.5%. The most risky work positions experienced were bending (50.3%), sitting for a long time (54.8%), and lifting (55.2%). Based on the results of in-depth interviews, it is known that seaweed farmers prefer not to access health facilities in handling MSDs complaints and tend to relax in the traditional way through massage methods using massage oil, rest and consume coffee or tea in warm conditions. It is hoped that the relevant agencies will provide education regarding the prevention and handling of MSDs complaints to seaweed farmers.