This study aimed to describe how the microbiology practicum process was implemented for biology education students at UIN Alauddin Makassar during COVID-19. The type of research applied in this study was descriptive-quantitative. The sample for this study consisted of 54 biology education students from the 2018 class. The instruments used included student response questionnaires, interviews with lecturers and students, and observation sheets. The data analysis technique employed was descriptive statistical analysis. With an average score of 89%, the results showed that the preliminary practicum activity implementation went very well. The working phase of practicum activities was also carried out very well, with an average score of 88%. Lastly, the closing stage of the practicum activities was performed very well, with an average score of 86%.