In the era of the industrial revolution 4.0, educators must be able to innovate, especially in the teaching and learning process, so that learning can be more optimal and exciting. Technological developments require educators to have skills, be able to innovate, think critically, communicate, and master technology. This research aims to find out how universities utilize blended learning as an innovation in learning in the 4.0 industrial revolution era in universities.  This type of research is library research which discusses blended learning as a learning innovation in the era of the industrial revolution 4.0 in tertiary institutions. The technique used in this study to collect data is using documentation obtained through books and journals that are relevant to the topics discussed in this paper. This study uses data analysis techniques, namely content analysis. Learning innovations using blended learning provide opportunities for students with various characteristics to learn independently and sustainably throughout their lives so that learning will be effective, efficient, enjoyable, and fun. The design is based on Behaviorism and cognitive constructivist learning theory with the specifications of its components including 1) learning outcomes, 2) material organization maps, 3) reference lists, 4) teaching materials/materials, 5) synchronous and asynchronous learning activities, 6) learning designs asynchronous, 7) synchronous learning design, 8) synchronous learning flow.