Fatigue is a physical and mental state that experiences a decrease in work quality. Fatigue is an accumulation of various human physical activities; fatigue can also be interpreted as a body protection mechanism to avoid further damage recovery occurring after rest. Fatigue is often overlooked by workers when it is related to protecting workers' health. This study aims to determine the factors related to work fatigue experienced by PT PLN ULP Kalumpang, Bulukumba employees, namely age, length of service, work period, work period index, and temperature. The sampling technique used a total sampling of 45 employees. Method The research used is quantitative research using a cross-sectional questionnaire approach. The results of the study on employees at PT.PLN ULP Kalumpang, Sapalohe Village, Bonto Nautical District, Bulukumba Regency showed that age (P value 0.004), length of service (P value 0.000), work period (P value 0.024), Body Mass Index/BMI (P value 0.040), and temperature (P value 0.001) have a significant relationship to work fatigue in employees. Therefore, companies are expected to pay more attention to work fatigue experienced by their employees by implementing a healthy lifestyle and paying attention to workers' rest schedules to increase employee work productivity.