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Air quality is a parameter that measures the condition of air that is suitable for an area. The Air Quality Index (IKU) is one of the instruments that can be used to conduct a simple air quality assessment using several selected parameters, namely nitrogen dioxide (NO2) and sulfur dioxide (SO2). Air pollutant gases that impact health, especially the respiratory system, are NO2 and SO2. This study aims to determine the ambient air quality of nitrogen dioxide (NO2) and sulfur dioxide (SO2) based on the air quality index in 24 regencies/cities in South Sulawesi Province in 2015-2021. This study uses a quantitative research method with a descriptive approach. The data used is secondary data obtained from several sources such as government agencies and official government websites, namely the website of the Ministry of Environment and Forestry, DPLH (Environmental Management Service) of South Sulawesi Province and P3E SUMA (Sulawesi & Maluku Ecoregion Development Control Center). The results of this study indicate that air quality in 24 regencies and cities in Sulawesi Province based on the average Concentration of NO2 and SO2 parameters from 2015-2021 is still below the ambient air quality standard value based on Appendix VII of Government Regulation of the Republic of Indonesia Number 22 of 2021 concerning the Implementation of Environmental Protection and Management. Furthermore, the Air Quality Index (IKU) in 24 regencies and cities in South Sulawesi Province in 2015-2021 was, on average, in the good category. However, the government and related parties are expected to continue to take preventive measures so that the concentration of NO2 and SO2 in ambient air does not increase and that the air quality in South Sulawesi Province is always in good condition.