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This study explores the issue of transgender identity from the perspective of the Qur'an, aiming to examine how Islamic scripture addresses this topic—the research problem centers on understanding the Qur'anic stance on transgender issues and gender transition practices. This article applies a thematic approach combined with library research methodology, which involves a systematic review and analysis of various Qur'anic verses related to gender identity, human nature, and permissible actions. Relevant verses were gathered to construct an overarching view of the permissibility and implications of gender transition from an Islamic standpoint. Findings indicate that Islam, as conveyed through the Qur'an, strictly prohibits acts involving gender alteration, whether transitioning from male to female or vice versa. The Qur'anic perspective emphasizes the significance of preserving the inherent nature (Fitrah) assigned by Allah, viewing any attempt to change one's gender as a contradiction to divine creation and natural order. Moreover, the Qur'an associates altering physical identity and gender with acts of rebellion against the boundaries set by God, suggesting moral and spiritual consequences for those who engage in such practices. Through its thematic analysis, the study reveals that Islamic teachings strongly discourage interventions aimed at changing one's biological sex or social gender identity, advocating instead for acceptance and adherence to one's divinely ordained nature. These findings contribute to broader discussions on gender identity within Islamic ethics, particularly highlighting the religious objections to gender transition as reflected in Islamic scripture.