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This study investigates the factors influencing employee performance in public sector hospitals in Sudan during periods of conflict. The research focuses on four key variables: physical well-being, work conditions, motivation, and job satisfaction. Data was acquired using quantitative approaches through questionnaires. The study encompassed all healthcare practitioners at government hospitals in Khartoum, employing random selection techniques to guarantee a representative sample. The essential data was collected using a questionnaire that employed a 5-point Likert Scale. An assessment was conducted to determine the accuracy and consistency of the instrument. The data was subjected to classic assumption tests, such as normality, F test, R2 test, and t-test, to verify its accuracy and reliability. The results of this study indicate that physical well-being, work conditions, and level of job contentment have a constructive and noteworthy impact on the effectiveness of employees in public sector hospitals in Sudan. However, motivation has a negligible effect on employee performance. These findings emphasize the significance of enhancing physical well-being, optimizing the work environment, and augmenting job satisfaction to enhance performance in public sector hospitals. These insights serve as a foundation for additional study and practical treatments designed to improve employee performance in the healthcare industry during conflict situations.