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The main problem in this research is what is the potential of university business incubators in West Sulawesi? What is the government's role in supporting university business incubators in West Sulawesi? And what is the strategy model for developing a business incubator in empowering entrepreneurs based on local wisdom in West Sulawesi. The type of research used in this research is qualitative research with an ethnographic approach. This research was located at Alasyariah Mandar University, Polewali Mandar Regency and West Sulawesi University, Majene Regency. Data collection methods through observation, interviews and documentation. Data analysis is carried out by reducing research data, displaying (presenting data) and drawing conclusions. The results of this research reveal that the potential for university business incubators in West Sulawesi has great potential to develop, this is demonstrated by the potential for tourism, culinary and plantations as well as the number of existing UMKM. The government's role in supporting university business incubators in West Sulawesi does not yet exist because there are no regulations and special budget allocations in developing business incubators in universities. As for the development strategy model carried out in local wisdom-based entrepreneurial empowerment efforts, namely being involved in the Ministry of Education and Culture's programs through matching fun, empowering villages, UMKM and BUMDES, also involving entrepreneurs, UMKM in expo activities which are held every year in College.