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Nosocomial infections or Healthcare-Associated Infections (HAIs) are serious issues threatening patient safety and quality of healthcare service. This study analyses effective hospital management practices that enhance coordination and communication among healthcare workers to prevent nosocomial infections. Through a Systematic Literature Review (SLR) approach, this study identifies and synthesizes empirical evidence from previous research. The results indicate that factors that prevent nosocomial infections include patient and family health education, strengthening surveillance systems and healthcare worker training, implementing hand hygiene programs, prudent antibiotic management, and improving motivation and compliance with infection prevention protocols among healthcare workers. Effective leadership, provision of adequate facilities, and support from hospital management are vital to the success of nosocomial infection prevention programs. This study provides practical recommendations for hospitals to optimize management in preventing nosocomial infections, such as improving healthcare worker coordination and communication, ensuring accurate reporting and surveillance, and strictly implementing infection prevention policies and guidelines. These findings contribute to developing comprehensive strategies to address the challenges of nosocomial infections and enhance overall healthcare quality.