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This research aims to: 1) Analyze the level of need for developing the P-Prof Application based on Islamic values ​​in mathematics learning at MAN 1 Soppeng; 2) Analyze the level of validity, practicality and effectiveness of the P-Prof application based on Islamic values ​​in mathematics learning at MAN 1 Soppeng. The type of research used is Research and Development (R&D) with a 4D model consisting of Define, Design, Develop and Disseminate. This research was carried out at MAN 1 Soppeng, with research subjects consisting of small group trials (10 students) and field trials (30 students). Data sources include documents, students, subject teachers, and experts/validators. Data collection methods include questionnaires, learning outcomes tests, interviews, and documentation. Data processing and analysis techniques through qualitative and quantitative methods. The research results show that the P-Prof application based on Islamic values ​​has a level of validity with a material expert assessment of 81.94% (valid category) and a media expert assessment of 76.79% (valid category). The level of practicality based on teacher responses was 85.71% (convenient category), small group student responses were 83% (convenient category), and large groups were 83.50% (convenient category). The level of effectiveness can be seen from the increase in the average score from the pre-test (60.27) to the post-test (82.2), with an N-Gain of 0.63 (effective category). The research results show that the Android-based P-Prof application is suitable because it effectively increases students' interest and learning outcomes in mathematics.