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Empowerment is a complex and multidimensional approach in overcoming inequality and social disability. Micro, Small and Medium Enterprises Empowerment has emerged as a potential solution in overcoming various social and economic challenges, especially in developing countries such as Indonesia. This study aims to identify the real contribution of IAIN Parepare in supporting the empowerment of Micro, Small and Medium Enterprises in Parepare City. The method used is a qualitative descriptive method. Data collection was conducted through in-depth interviews with Micro, Small and Medium Enterprises owners and the chairman of the Institute for Research and Community Service (LPPM) and IAIN Parepare Lecturers. In addition, documentation and observation are also carried out to gain a deeper understanding. Sampling of Micro, Small and Medium Enterprises using the snowball sampling technique. The results of the study show that IAIN Parepare has made positive contributions, namely: 1) Having a Commitment to Empowering MSMEs, 2) Organizing MSME Education and Training Activities, 3) Providing Consulting Services and Business Assistance for MSMEs, 4) Providing Information on Research Results on MSMEs, 5) Providing Access to Resources, and 6) Encouraging MSME Network and Cooperation.