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The aim of this research is to find out the effect and the significant difference of words chain game for students’ vocabulary mastery at Junior High School 2 Kotagajah. Word chain game is a game which the player uses the last letter of the preceding word to build a new word. This research used quasi experimental design. The subjects of this research are the eighth-grade students at Junior High School 2 Kotagajah academic year 2022. The result of data analysis indicates that value of t obtained (to) is higher than the value of t table (2.875>2.042). Moreover, the second data indicates t obtained (to) is higher than the value of t table (3.402>2.042). The conclusion is teaching English vocabulary using word chain game is effective to increase students’ vocabulary mastery and gives a significant difference.