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This research discussed about GIST strategy and reading comprehension. The aim of this research is to examine the Effect of Using GIST Strategy toward Students’ Reading Comprehension. The objectives of the research were about the students’ reading comprehension and significant effect of using GIST strategy toward its skill. This research was conducted at SMA Negeri 10 Gowa in Academic Year 2021/2022. The design of the research was pre-experimental with one group pre-test post-test design. The population was 180 students and the researcher took 36 students from XI IPA/3 purpossively. The instrument was used to collect the data was test, in multiple choices text. The research findings showed that the students obtained score on pre-test with the mean score 45.7 which classified as low. After giving treatment the students obtained improvement, they gained score with the mean score 70 as a reasonable classification. The result of the data analysis indicated that there was an increase in students’ reading comprehension after being taught using GIST strategy. It was proved by the result of the statistical analysis of the level significance 0.05 with degree of freedom (df) 35 indicated t-test values of the students’ reading comprehension (30.63) was higher than t-table value (2.042). Based on the result analysis, the impact of this research on the students makes the students understand meaning of words or the most important parts of text and get the details and specific information from it. GIST strategy also make students more active and creative in learning process. The researcher found that the strategy helps the students to understand the text especially in narrative text.