Background: Non Alcoholic Fatty Liver Disease (NAFLD) is a degenerative disease that is closely related to obesity. This disease does not only affect in adults, but can also attack children with the highest prevalence of obesity in adolescents. This is influenced by lifestyle patterns and daily food consumption. Research purposes :The purpose of this study was to see the effect of giving a high-fat, high-sugar diet to histological image of wistar rats liver with  control group. And the comparison the liver weight of the treatment group and the control group. Method :This study is a laboratory experimental with 8 white rats (Rattus Novergicus) Wistar strain aged 8 weeks with a body weight of 180 grams and adapted for 2 weeks and divided into 2 groups, namely the treatment group (feeding with high fat diet and high sugar drinks) and control group (standard feed and drink) with ad libitum feeding and drinking for 7 weeks. Data analysis was performed using the Independent T test. Results: The mean ratio of liver weight was greater in the treatment group (A) by 12.75 grams compared to the control group by 9.25 grams. The percentage of liver cell damage in the treatment group was greater than the control group with an average value of the treatment group (A) by  91.10% and the control group (B) by 4.07% (p = 0.000). Conclusion: The treatmet of a high-fat, high-sugar diet can affect changes in the liver image of wistart rats with the highest percentage of damage in the treatment group compared to the control group and also affected the highest liver weight in the treatment group compared to the control group.