Background: The incidence of preeclampsia in Indonesia for the Southeast Asian continent is still very high, namely 190/100,000 live births. Globally, according to WHO, about 12% of maternal deaths are caused by preeclampsia. Preeclampsia can cause disturbances to the mother and fetus in the form of hypovolemia, vasospasm, uteroplacental, infection, acute kidney disease, eclampsia, stroke, coagulopathy and respiratory syndrome and even death. Preventive measures can be taken by administering 5 finger hypnosis and murottal therapy which has benefits in the form of stabilizing blood pressure, pulse, breathing and activating endorphins. Methods: This research method is quantitative. The research design used a quasi-experimental one group pre-post test. This study uses 5 finger hypnosis and murottal intervention to prevent preeclampsia in pregnant women. The data analysis used in this research is univariate and bivariate analysis. Univariate analysis was conducted to see the characteristics of the sample, namely age, education and parity using descriptive analysis test. Bivariate analysis was carried out to see the effect and differences in the results of blood pressure measurements before and after the intervention using the Wilcoxon test. Results: The results of this study were tested using the SPSS version 26 application. The data were not normally distributed so that the test used was the Wilcoxon test. The results of this study indicate that pregnant women are at risk of experiencing preeclampsia with the characteristics of age as many as 9 pregnant women, education of 14 pregnant women and parity of 24 pregnant women. This study also found a significant difference between the pretest and posttest with an average decrease in blood pressure of 2-6 mmHg. Wilcoxon test results obtained p-values of 0.00 or (<0.05). Conclusions: Based on the results of the research above, nursing interventions based on 5 finger and murottal hypnosis modules have significant results in preventing preeclampsia. Researchers hope that there will be socialization in a larger population about the 5 finger and murottal hypnosis intervention module to prevent preeclampsia.