Last modified: 2022-09-30
Abstract
Background: After oral administration of the drug, drug dissolution is a requirement for absorption of a drug into the systemic circulation. Based on the classification Biopharmaceutical Classification System(BCS), ibuprofen is included in class II, which has low solubility with good permeability characteristics (effective permeability in humans for ibuprofen 8.70×10-4cm / s). Self-Emulsifying Drug Delivery System(SEDDS)can improve the bioavailability of drugs that have low solubility with high permeability. Therefore, to increase the dissolution rate, a ibuprofen formulation was carried out using the SEDDS method. The aim of sedds formation is to increase the solubility and onset of action of ibuprofen, thereby improving therapeutic effectiveness. Methods: Ibuprofen solubility tests were carried out on several types of oil and surfactants, namely corn oil, sunflower oil, soybean oil, oleic acid, tween 80 and span 80 using the method saturation solubility. Three formulas were made containing the active ingredient ibuprofen 200 mg, Tween 80: span 80 (3: 1) as a surfactant with a concentration of 30% (F1), 45% (F2), 60% (F3) and oil as a carrier. The preliminary characterization of ibuprofen SEDDS was determined by emulsification efficiency method, dispersibility test and particle size characteristics. Results: The results of the solubility test showed that oleic acid had the highest dissolving capacity of 29.11% so that oleic acid was used as a carrier in this formulation. The dissolution test results showed that the ibuprofen formulated by the SEDDS method could increase the dissolution rate of ibuprofen, the dissolution percentage of each formula after 1 hour was 72.44% (F1), 65.27% (F2), 85.10% (F3), and 33.65% comparison. Statistical analysis using a completely randomized design showed a significant difference between dissolution rates (F1), (F2) and (F3) with comparators. The ibuprofen formula with surfactant of 60% (F3) showed the highest dissolution rate compared to (F1) and (F2) as well as with comparators. Conclusions: The formation of ibuprofen SEDDS with 60% surfactant consentration (F3) was proven to increase the dissolution rate of ibuprofen.