Communication between doctors and patients is one of the keys to the success of providing good medical services to patients. With good and effective communication, health services will be more optimal, and patients will feel more comfortable and satisfied. Furthermore, the risk of malpractice could be reduced. Among several elements influencing effective communication in a doctor-patient relationship, empathy is considered to play a significant role. Empathy is a person's ability to emotionally understand what other people feel and experience. Essentially, it is the ability to put ownself into someone else’s position. The empathic feeling is highly needed in doctor-patient communication. As a communication competence has been consistently cited as a key element in the medical profession, empathy is central to be possessed by doctors in building proper and decent communication with their patients. Empathy has been instrumental for doctors to build deeper sense of feelings which may lead to attention and compassion on patients’ condition. Moreover, emphatic feeling has a pivotal role enabling doctors to observe a sensory or affective of patients to identify and understand their emotional experience. The major purpose of this research was to investigate the attainment of doctor-patient effective communication through empathic feeling. The methodological approach used in this research was quasi experimental research by utilizing a pre-experimental one group pretest-posttest design. The sample of this study consisted of 96 medical students selected from the Faculty of Medicine and Health Sciences of Alauddin State Islamic University of Makassar. Following the statistical test using paired t-test, a correlation test result with a Sig value of 0.01 was obtained. With the level of significance/alpha : 0.05, it is obvious that the significant value is 0.01 < 0.05 showing that H0 is rejected and Ha is accepted. Therefore, doctor-patient effective communication has been considered to influence the students’ level of empathy.