Introduction :The aimed of this study was to analyze the correlation between the expression of gene and protein COMT with the memory capabilities of al-Qur'an memorizers. Method :This study was done by quantitative research, using observational methods with the cross-sectional approach. The sample selection was done purposively. The memory ability was measured based on Intelligence Structured Tests (IST) and ELISA was performed to determine COMT protein levels. Result : A significant correlation was found between age, gen and protein COMT  with memory scores in the respondents. Conclussion:The younger age and the high number of COMTs correlated with increasing memory skills in memorizing the Qur'an.