Media is an important part that can engage students to learn. This research aims to determine This research aims to determine the effect of the CSC (Clue & Search Card) learning media on plant tissue material on the learning outcomes of class XI students at MAN 1 Makassar. This research method was Quasi Experimental using a Nonequivalent Control Group Design. The population of this study included all students in class XI MIPA at MAN 1 Makassar. Class XI MIPA 3 acted as the control class and XI MIPA 4 as an experimental class. Each class consisted of 35 people that were selected through the purposive sampling technique. The instruments used were an observation sheet and a 25-item learning outcomes test. The data analysis techniques used were descriptive and inferential analysis, including normality tests, homogeneity tests, and hypothesis tests. The results showed that the learning outcomes score in the experimental class had an average of 85.31, which was in the very good category, while the control class had an average of 57.37 in the sufficient category. Inferential statistical analysis showed a sig value. of 0.000, indicating that sig. α = 0.000 < 0.05, so H0 is rejected and H1 is accepted. These results reveal that there is an influence of CSC (Clue & Search Card) learning media on plant tissue material on the learning outcomes of class XI students at MAN 1 Makassar.