Learning media is essential in teaching and learning because it can influence student learning outcomes. This research aims to develop a valid, practical, and effective podcast-based audio learning media on respiratory system material for class XI MIA 2 MA Madani Alauddin Pao-Pao.This study type is research and development (R&D) based on the ADDIE model, which consists of five steps: analyze, design, develop, implement, and evaluate. This research was conducted at MA Madani Alauddin Pao-Pao with research subjects, namely class XI MIA 2, totaling 30 students. The instruments used were validation sheets, questionnaires, test questions, and validated lesson plans.The findings showed that the very valid category had a media validity score of 3.66. Teachers responded to the media's practicality in the very practical category with 92.85%, while students responded in the practical category with 79%. Of the 30 total students, 25 of them got scores above the minimum completeness criteria (KKM) with a percentage of 83.33%, and 5 of them got scores below the KKM with 16.66%.This research implies that podcast-based audio media on human respiratory system material is suitable for application in the learning process both offline (outside the network) and online (in the network).