Guidance and counselling programs have a crucial role in the effective development of students, but the shortage of educators is often an obstacle. In the 5.0 Era, Darul Kamal NW Kembang Kerang Vocational High School in East Lombok implements an approach that involves not only the role of Counseling Guidance teachers but also collaboration with Islamic Religious Education teachers in the student education process to achieve an optimal level of success. This study aims to explore the synergy and contribution of Islamic Religious Education teachers in supporting the counselling guidance program in the school. A qualitative research method with a case study approach was used, involving in-depth interviews with Islamic Religious Education and Counseling Guidance teachers as well as participatory observation. The results of the study show three forms of synergy among Islamic Religious Education teachers, including informants, facilitators, and collaborators. These roles assist the school in providing comprehensive guidance to optimize students' potential. The study also identified two forms of cooperation between Islamic Religious Education teachers and Counseling Guidance teachers, namely in student identification and collaboration with parents. This shows that the student guidance process involves comprehensive collaboration between teachers, Counseling Guidance, and guardian parents.